megaloblastic anemias การใช้

• The consequence of reduced methionine synthase activity is megaloblastic anemia.
• Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia.
• This may result in megaloblastic anemia.
• They are not seen in healthy blood, and are most commonly seen in megaloblastic anemia.
• Differences lie in the presentation of megaloblastic anemia induced by either folate or B 12 deficiency.
• Bone marrow ( not normally checked in a patient suspected of megaloblastic anemia ) shows megaloblastic hyperplasia.
• A lack of methylcobalamin can lead to megaloblastic anemia and subacute combined degeneration of the spinal cord.
• Forms of vitamin B 12 deficiency other than PA must be considered in the differential diagnosis of megaloblastic anemia.
• Sulfasalazine inhibits dihydropteroate synthase, and can cause folate deficiency and megaloblastic anemia . and various other undesirable effects.
• Neurological effects are not often associated with folate-related megaloblastic anemia, although demyelinating disorders may eventually present.
• Vitamin B 12 deficiency is potentially extremely serious, leading to megaloblastic anemia, nerve degeneration and irreversible neurological damage.
• It is also associated with growth retardation, megaloblastic anemia, pectus excavatum, scoliosis, vomiting, diarrhea, and hepatosplenomegaly.
• This introduces the risk of the child developing electrolyte imbalances, metabolic acidosis, megaloblastic anemia, and a host of allergic reactions.
• Granulocytopenia, agranulocytosis, and red-cell hypoplasia and aplasia, and megaloblastic anemia are rarely associated with the use of primidone.
• Beginning in the second year of life, a particularly striking feature of LNS is vitamin B 12, some boys may develop megaloblastic anemia.
• Serum B12, Malonic Acid, Schilling Test, Complete Blood Count-looking for megaloblastic anemia if there is also folic acid deficiency or macrocytic anemia
• The relationship between folate and B 12 is so interdependent that deficiency in either vitamin can result in megaloblastic anemia, characterized by organic mental change.
• Megaloblastic anemia related to deficiency in B 12 generally results in peripheral neuropathy, whereas folate-related anemia often results in affective, or mood disorders.
• An example is the hypersegmented neutrophil, which is seen only in megaloblastic anemias ( not a single disease, but a set of closely related disease states ).
• Orotic aciduria is associated with megaloblastic anemia due to decreased pyrimidine synthesis, which leads to decreased nucleotide-lipid cofactors needed for erythrocyte membrane synthesis in the bone marrow.